The first batch of patents open for licensing or transferring in 2025

Name

An anticancer bioactive peptide and a synthesis method thereof

Field

Anti-cancer technical field

Invention Patent Number

ZL 202110623109.0

Inventor

Siew Woh Choo, Li Chen, Lanni Song, Xuechen Tian

Application Background

Polypeptide anticancer drugs are a hot spot in the research and development of anticancer drugs recently. Bioactive peptides are a class of peptide compounds that have special physiological effects on organisms.

Patent Introduction

An object of the present invention is to provide an anticancer bioactive peptide comprising an amino acid sequence as shown in the figure and a synthesis method. The active peptide is safe and effective, and has obvious anticancer effect. The active peptide has obvious inhibitory effect on the proliferation of cervical cancer cells, lung cancer cells and melanoma cells, and can obviously inhibit the migration of melanoma cells and cause them to undergo obvious apoptosis. The active peptide has no significant effect on the cell viability of normal cells.

Name

An Anti-Inflammatory Polypeptide And Correspondence Synthesizing Method

Field

Pharmaceutical preparation field

Invention Patent Number

ZL 202110622991.7

Inventor

Siew Woh Choo, Haojie Lin, Zhengyi Lin, Haiyi Zhao, Xuechen Tian

Application Background

Inhibiting the synthesis or activity of inflammatory mediators has become the mainstream in the treatment of inflammation, and commercially available anti-inflammatory drugs are often accompanied by side effects, even serious adverse reactions. Therefore, it is of great significance to develop new anti-inflammatory drugs that are efficient, safe and highly targeted.

Patent Introduction

The invention discloses an anti-inflammatory polypeptide and a synthetic method, which comprises a polypeptide having an amino acid sequence shown in the following figure or an active fragment or analog or derivative thereof.

Such polypeptides have inhibitory effects on inflammatory factors IL-8, IL-6 and MMP-3 in inflammatory model cells, and do not significantly affect the viability of normal human cells. They are safe and non-toxic, and have good industrialization prospects.

Name

A composition and antibacterial usage thereof (transferred)

Field

Pharmaceutical preparation field

Invention Patent Number

ZL 202111195294.4

Inventor

Siew Woh Choo, Li Chen, Kunping Song, Xuechen Tian

Application Background

In the prior art, a variety of weakly acidic antibacterial and antiseptic effects have been confirmed, but the application of organic acids directed to the inhibitory effects of Escherichia coli and Staphylococcus aureus, which have the most widespread and frequent effects on human diseases, has not been found. By studying the components of pangolin scales with good bacteriostatic effect, the invention explores the composition of metabolites used for bacteriostatic in pangolin scales, so as to realize the bacteriostatic effect of multi-combination weak acid replacing pangolin scales.

Patent Introduction

The invention provides a composition and an antibacterial application thereof, which can be applied to a human body and an environment in which the human body is located, and can reduce the propagation tendency of microorganisms existing therein. The minimum inhibitory concentration used by the composition for inhibiting Escherichia coli and Staphylococcus aureus is 2.5 times lower than that used by ordinary acidic compositions for inhibiting bacterial flora alone.

Name

Combination of human interferon -ε and interferon -γ and its usage (transferred)

Field

Pharmaceutical preparation field

Invention Patent Number

ZL 202010241103.2

Inventor

Siew Woh Choo, Xuechen Tian

Application Background

Interferon has become one of the most widely used anti-cancer and antiviral drugs since it was put into the market. Because of the late discovery of interferon-ε, the research on it is far inferior to that of other interferons of the same type. Therefore, it is of great clinical significance to explore the combination of interferon-ε and interferon-γ in the field of anti-tumor application, especially in malignant epithelial tumors represented by melanoma and cervical cancer.

Patent Introduction

The invention discloses a combination drug of interferon-ε and interferon-γ and application thereof, and the combination drug is used in tumor treatment synergistically. The combination drug of interferon-ε and interferon-γ can obviously inhibit the proliferation of melanoma cells and cervical cancer cells, and has a good application prospect in tumor treatment.

Name

An anti-inflammatory polypeptide and its synthesis method

Field

Pharmaceutical preparation field

Invention Patent Number

ZL 202311166938.6

Inventor

Siew Woh Choo, Haojie Lin,Haohong Tu

Application Background

Inhibiting the synthesis or activity of inflammatory mediators has become the mainstream in the treatment of inflammation. However, commercially available anti-inflammatory drugs are often accompanied by side effects and even serious adverse reactions. Therefore, it is of great significance to develop new anti-inflammatory drugs with high efficiency, safety and strong pertinence.

Patent Introduction

The invention discloses an anti-inflammatory polypeptide and a synthetic method, wherein the anti-inflammatory polypeptide is a polypeptide comprising the amino acid sequence of AERRVPFSL or an active fragment or analog or derivative of the polypeptide; The amino acid sequence of the polypeptide, analog or derivative is not less than 85% identical to the amino acid sequence AERRVPFSL. The anti-inflammatory polypeptide synthesized by the synthesis method provided by the invention has high purity, and the purity can reach 95.2%; It is safe and non-toxic, and has no effect on the cell activity of human immortalized keratinocytes; Can effectively inhibit the expression of inflammatory factors.

Name

Solubility and Pharmacokinectic Profile Improvement of Griseofulvin Through Supercritical Carbon Dioxide Assisted Complexation with HP-γ-Cyclodextrin

Field

Pharmaceutical preparation field

Invention Patent Number

ZL 202211198872.4

Inventor

Yingli Ding , Lu Li

Application Background

As a non-polyene antifungal antibiotic, griseofulvin is widely used to treat fungal infections of the skin and stratum corneum. How to improve the solubility and dissolution of griseofulvin has become the focus of clinical practice.

Patent Introduction:

The technical means of the invention improves the water solubility of the griseofulvin by designing the inclusion complex of the griseofulvin and the cyclodextrin, discloses the complex structure of the cyclodextrin structure and the griseofulvin, the water solubility of the prepared product is 477 times higher than that of the original drug under the atmosphere of supercritical carbon dioxide, 90% of the griseofulvin is released within 10 minutes, and the AUC of the in vivo pharmacokinetic study is increased by 178%.

Name

Synthesis of Lactosyl Conjugated 6A, 6D-Bifunctionalized β-Cyclodextrin Derivatives as Potential Iver Cancer Drug Carriers

Field

Pharmaceutical preparation field

Invention Patent Number

ZL 202310543450.4

Inventor

Yingli Ding,Zhe Xu

Application Background

Sorafenib, a VEGFR, PDGFR and RAF kinase inhibitor, was approved by the FDA in 2007 as a targeted drug for the treatment of advanced liver cancer. Cyclodextrin can improve the solubility and stability of drugs, and has the ability to form host-guest inclusion complexes. The selective functionalization of these cyclic oligosaccharides can significantly improve their complexation ability with drugs (such as sorafenib with low water solubility, etc.) and drug targeting ability.

Patent Introduction:

According to the present invention, the corresponding amino derivatives are prepared from monolactose-conjugated β-cyclodextrin compounds. These important intermediates link other molecules with specific biological activities to form bifunctional cyclodextrins. The invention obtains lactosyl 6A, 6D-bifunctionalized β-cyclodextrin derivatives by connecting fondaparin or folic acid. These cyclodextrin derivatives can be used as potential carriers for liver cancer and other anticancer drugs to improve the targeting ability, solubility and stability of anticancer drugs, and have good application prospects.

Name

A fenbendazole methyl-β-cyclodextrin inclusion complex and its preparation method

Field

Pharmaceutical preparation field

Invention Patent Number

ZL 202410401056.1

Inventor

Yingli Ding,Zhe Xu

Application Background

Fenbendazole is an effective oral benzimidazole anthelmintic, which has the characteristics of wide anti-parasitic activity, high efficiency and low toxicity, and is widely used in agriculture and animal husbandry to control parasites. As a microtubule destabilizer, fenbendazole has also shown anticancer effects against several cancer types, as well as against paclitaxel and doxorubicin-resistant cancer cells.

Patent Introduction

The fenbendazole methyl-β-cyclodextrin inclusion complex provided by the invention is formed by reacting fenbendazole with methyl-β-cyclodextrin, and the solubility is increased to 20.21 mg/mL, which is the best effect so far and is 60,000 times higher than that of the effect of inclusion of fenbendazole alone. Moreover, in vivo pharmacokinetic studies, the release amount of fenbendazole within 15 minutes was 75%, and the bioavailability of fenbendazole and its main metabolic insect repellent orfendazole and its secondary metabolic insect repellent orfendazole increased to 138%, 149% and 169% respectively, which made them achieve the same therapeutic effect at a smaller dose, indicating that the inclusion complex can be used as a potential anticancer drug.

Name

Grating guide plate

Field

Guide sign

Invention Patent Number

ZL 202121062878.X

Inventor

Yaoyao Huang

Application Background

In order to meet the needs of public places, the existing guide signs mostly need to take into account Chinese and English bilingual guide information for typesetting design. However, the common bilingual typesetting increases the demand for the area of guide signs to a certain extent. Designers mostly expand the area or reduce the font size to realize the compatibility of bilingual typesetting, but the public generally only needs one of the languages to read information, and the reduction of font size weakens the identification and guidance of guide information.

Patent Introduction

A grating guide plate comprises a mounting structure and a plate body, wherein the plate body is fixed to the mounting surface through the mounting structure, and is characterized in that the plate body comprises a supporting layer and not less than one grating layer, the lower surface of the grating layer is attached to the supporting layer, and the lower surface of the grating layer is printed with an identification image, the identification image is spliced by several image strips of the identification image to be displayed, and the number of identification images to be displayed is two, which are Chinese identification image and foreign identification image respectively. The visual characteristics of different patterns can be displayed at different angles by grating, and the bilingual logo images can be displayed at different angles respectively, which solves the problem of complicated and crowded bilingual logo layout. The logo image extracted from a fixed perspective is simplified and easy to identify; The bilingual guidance of bilingual signs is retained, which is convenient for personnel guidance and communication between different languages

Name

Table lamp (Memories of the Village)

Field

Ornament decoration

Design Patent Number

ZL 202230671862.2

Designer

Maurizio Vrenna, Xinyuan Xu

Purpose

Used for lighting and ornament decoration.

Stereoscopic View

Name

(Lakes and mountains)

Field

Ornament decoration

Design Patent Number

ZL 202230671862.2

Designer

Maurizio Vrenna, Chenyou Zhao

Purpose

Used for lighting and ornament decoration.

Stereoscopic View

Name

Wall Light (Clean Lake)

Field

Ornament decoration

Design Patent Number

ZL 202230672179.0

Designer

Maurizio Vrenna, Yizheng Zhu

Purpose

Used for lighting and ornament decoration. The appearance of this product is fictional lake.

Stereoscopic View

Name

Table Lamp (Golden Dawn)

Field

Ornament decoration

Design Patent Number

ZL 202230672179.0

Designer

Maurizio Vrenna, Yixuan Chen

Purpose

Used for lighting and ornament decoration.

Stereoscopic View

Name

Table lamp (Ginkgo)

Field

Ornament decoration

Design Patent Number

ZL 202230672176.7

Designer

Maurizio Vrenna, Jialei Wu

Purpose

Used for lighting and ornament decoration.

Stereoscopic View

Name

Environmental-friendly slow-release fertilizer equipment for landscaping seedlings

Field

Relates to the technical field of slow-release fertilizer equipment, in particular to an environmentally friendly slow-release fertilizer equipment for landscaping seedlings

Utility Model Patent Number

ZL 202122291345.5

Designer

Hui Zhao

Application Background

Under normal circumstances, after nitrogen fertilizer is applied to the soil, only 30-50% can be absorbed and utilized by crops, while the rest is lost in vain, resulting in the loss of nitrogen fertilizer, which is caused by the volatilization and leaching of ammonia, nitrification and denitrification. The purpose of developing and applying slow-release nitrogen fertilizer is to reduce the dissolution rate of nitrogen fertilizer, make nitrogen fertilizer provide nitrogen for crops one after another during the slow dissolution process, and prevent adverse consequences such as damaging crop seeds, seedlings or burning leaves due to excessive local concentration.

Patent Introduction

The utility model relates to an environmentally friendly slow-release fertilizer equipment for landscaping seedlings. By setting up a positioning mechanism and a limiting mechanism, the positioning mechanism is fixed on the landscaping seedlings, the fertilizer slow-release bag is stable and convenient to install, is not afraid of wind blowing, will not be blown down in windy weather, and the limiting mechanism positions the infusion tube to avoid the dripping position of nutrient solution in the infusion tube.

Name

Wild camping connecting piece

Field

Guide sign

Utility Model Patent Number

ZL 202323045026.1

Designer

Yinxuan Zhou,Xinyuan Xu,Shihan Zhang

Application Background

In the existing camping products, kitchen utensils or tripods needed for lighting need to be carried by themselves, resulting in many things to be carried with you during camping and inconvenient travel.

Patent Introduction

The invention relates to an outdoor camping connector, wherein the lower end of the base is provided with a plurality of evenly distributed first convex components for connection, and the upper end of the cylinder is provided with a second convex component for connection, which is inserted into the gap between the first convex components through the second convex components, and is sequentially transversely passed through by bolts and then tightened and fixed by a nut to form a cylinder with adjustable angle. Has the advantages that the structure is simple, the angle of the cylinder body can be adjusted, the supporting cylinder body can be found on the spot, the problem of carrying the supporting cylinder body is avoided, and the baggage weight occurring in camping is reduced.

Name

Locker

Field

Decorate and store items

Design

Patent Number

ZL 202330728106.3

Designer

Yinxuan Zhou,Yizheng Zhu

Purpose

For decorating and storing items

Stereoscopic View

Name

Lamp

Field

Decorate and store items

Design

Patent Number

ZL 202330728105.9

Designer

Yinxuan Zhou,Yizheng Zhu

Purpose

For decoration and lighting

Stereoscopic View