OFFICE: GEH B404
EMAIL: aloysiusw@wku.edu.cn
ACADEMIC EXPERIENCE:
2016 Postdoctoral Researcher
Institute for Integrative Biology of the Cell (I2BC)
French National Centre for Scientific Research (CNRS) campus, France
2014-2016 Postdoctoral Fellow
King Abdullah University of Science and Technology (KAUST), Saudi Arabia
COURSE TAUGHT:
General Biology I
Principles of Biology
Biology & Society
Bioinformatics
EDUCATIONAL BACKGROUND:
PhD in Bioscience (2011-2014)
King Abdullah University of Science and Technology (KAUST), Saudi Arabia
MPhil in Biotechnology (2010-2011)
University of Cambridge, UK
BSc (Hons) in Biotechnology (2006-2009)
UCSI University, Malaysia
RESEARCH INTEREST:
Dr. Wong seeks to understand from a molecular perspective, how plants despite being sessile and immobile, can efficiently perceive environmental (biotic and abiotic) signals and mount short- and long-term biological responses that enables them to survive in environments considered hostile to plants. His current research can be divided into three main areas: 1) Sustainable and indoor horticulture, 2) Probiotics and antibiotic resistance and, 3) Plant cell signaling.
PUBLICATIONS:
Journal Articles
1. Su B, Qian Z, Li T, Zhou Y & Wong A (2019). PlantMP: a database for moonlighting plant proteins. Database (Oxford) 2019(2019), baz050
2. Bianchet C*, Wong A*, Quaglia M, Alqurashi M, Gehring C, Ntoukakis V & Pasqualini S (2019). An Arabidopsis thaliana leucine-rich repeat protein harbors an adenylyl cyclase catalytic center and affects responses to pathogens. J Plant Physiol 232(2019), 12-22 *Co-first author
3. Xu N*, Wang Y*, Zhu J, Ding M, Liu J, Jin X, He Y, Shen L, Jiang Y, Wang Y & Wong A (2018). Development of an online tracking tool for antibiotic resistance. Basic Clin Pharmacol Toxicol 124(52), 12
4. Al-Younis I, Wong A, Lemtiri-Chlieh F, Schmӧkel S, Tester M, Gehring C & Donaldson L (2018). The Arabidopsis thaliana K+-uptake permease 5 (AtKUP5) contains a functional cytosolic adenylate cyclase essential for K+ transport. Front Plant Sci 2018(9), 1645
5. Marondedze C, Liu X, Huang S, Wong C, Zhou X, Pan X, An H, Xu N, Tian X & Wong A (2018). Towards a tailored indoor horticulture: A functional genomics guided phenotypic approach. Hortic Res 2018(5), 68
6. Chatukuta P, Dikobe TB, Kawadza DT, Sehlabane KS, Takundwa MM, Wong A, Gehring C & Ruzvidzo O (2018). An Arabidopsis clathrin assembly with a predicted role in plant defense can function as an adenylate cyclase. Biomolecules 23(2), E15
7. Wong A*, Tian X, Gehring C & Marondedze C (2018). Discovery of novel functional centers with rationally designed amino acid motifs. Comput Struct Biotechnol J 16(2018), 70-76 *First & Corresponding author
8. Xu N, Fu D, Li S, Wang Y & Wong A (2018). GCPred: a web tool for guanylyl cyclase functional centre prediction from amino acid sequence. Bioinformatics 34(12), 2134-2135
9. Ooi A, Lemtiri-Chlieh F, Wong A & Gehring C (2017). Abscisic acid regulates the conductance of the guard cell outward rectifying K+-channel. Mol Plant 10(11), 1469-1472
10. Zheng M, Zhang R, Tian X, Zhou X, Pan X & Wong A (2017). Assessing the risk of probiotic dietary supplements in the context of antibiotic resistance. Front Microbiol 8, 908
11. Wheeler J, Wong A, Marondedze C, Arnoud G, Kwezi L, Freihat L, Jignesh V, Misjudeen R, Irving H & Gehring C (2017). The brassinosteroid receptor BRI1 can generate cGMP enabling cGMP-dependent downstream signaling. Plant J 91(4), 590-600
12. Ooi A, Wong A, Esau L, Lemtiri-Chlieh F & Gehring C (2016). A guide to transient expression of membrane proteins in HEK-293 cells for electrophysiological characterization.Front Physiol 7, 300
13. Ooi A*, Wong A*, Ng TK, Marondedze C, Gehring C & Ooi BS (2016). Growth and development of Arabidopsis thaliana under single-wavelength red and blue laser light. Sci Rep6: 33885 *Co-first author
14. Al-Younis I, Wong A & Gehring C (2015). The Arabidopsis thaliana K+-uptake permease 7 (AtKUP7) contains a functional cytosolic adenylate cyclase catalytic centre. FEBS Lett589 (24 Part B), 3848-3852
15. Wong A, Gehring C & Irving HR (2015). Conserved functional motifs and homology modeling to predict hidden moonlighting functional sites. Front Bioeng Biotechnol 82, 1-8
16. Wong A, Ngu DYS, Dan LA, Ooi ASL & Lim RLH (2015). Detection of antibiotic resistance in probiotics of dietary supplements. Nutr J 14, 95
17. Domingos P, Prado, AM, Wong A, Gehring C & Feijo J (2015). Nitric oxide: A multitasking gas in plants. Mol Plant 8(4), 506-520
18. Marondedze C, Wong A, Groen AJ, Serrano N, Jankovic B, Lilley KS, Gehring C & Thomas L (2014). Exploring the Arabidopsis proteome: Influence of protein solubilization buffers on proteome coverage. Int J Mol Sci 16(1), 857-870
19. Wong A & Gehring C (2013). The Arabidopsis thaliana proteome harbors undiscovered multi-domain molecules with functional guanylyl cyclase catalytic centers. Cell Commun Signal, 11(1), 48
CONFERENCE PROCEEDINGS:
1. Wong A (2018). Development of an online tracking tool for antibiotic resistance. Proceedings of the 2018 Americas Conference on Medical Imaging and Clinical Research (AMICR 2018). December 23-25, 2018, Panama City, Panama
2. Xu N, Zhang C, Lim LL & Wong A (2018). Bioinformatic analysis of nucleotide cyclase functional centers and development of ACPred webserver. Proceedings of the 2018 ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics (BCB’18). August 29-September 1, 2018, Washington DC, USA
3. Lu L, Michelena T, Wong A, Zhang C & Meng Y (2018). The inhibition of acetylcholinesterase by a brain-targeting polylysine-apoE peptide: biochemical and structural characterizations. Proceedings of the 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC’18). July 17-21, 2018, Honolulu HI, USA
BOOK CHAPTERS:
1. Wong A, Thomas L, Gehring C & Marondedze C (2016). Proteomics of fruit development and ripening. In Sunil Pareek (Ed.), Postharvest Ripening Physiology of Crops: CRC Press/Taylor & Francis, 413-448
2. Marondedze C, Wong A, Thomas L & Gehring C (2016). Non-canonical cyclic mono-nucleotides in plants. In R. Seifert (Ed.), From canonical to non-canonical cyclic nucleotides as second messengers: Pharmacological Implications, Handbook of Experimental Pharmacology: Springer Berlin Heidelberg, Switzerland 1-17 doi: 10.1007/164_2015_35
3. Wong A & Gehring C (2013). Computational identification of candidate nucleotide cyclases in higher plants. In C. Gehring (Ed.), Cyclic Nucleotide Signaling in Plants, Methods Mol Biol 1016, 195-205, Humana Press
PATENT:
Laser-based agriculture system, Ooi BS, Wong A & Ng TK. US 14/868,422; US20160088804 A1, March 31, 2016.
GRANTS:
1. National Natural Science Foundation of China (Grant No. 31850410470) – Principal Investigator
Category: International (Regional) Cooperation and Exchange Project
Project Title: Towards a highly tailored indoor horticulture: A functional genomics guided phenotypic approach
Duration: 2019-01-01 to 2020-12-31 (Amount: 399,600 RMB)
2. Zhejiang Provincial Natural Science Foundation of China (Grant no. LQ19C130001) – Principal Investigator
Category: Youth Science Fund Project
Project Title: 高级定制的室内园艺：一种功能基因组学引导的表现型途径
Duration: 2019-01-01 to 2021-12-31 (Amount: 97,000 RMB)
3. Student partnering with Faculty (SpF) II, III & IV (Grant No. WKU201617002, WKU201718009 & WKU201819002) – Principal Investigator
Project Title: Antibiotic resistant probiotics in dietary and health supplements
Duration: 2016-01-11 to 2020-01-03 (Amount: 88,700 RMB)
AWARDS:
1. Wenzhou-Kean University Student Research Days Keynote Speaker (04-2018)
2. Young Investigator Award by Young Scientist Network Malaysia & Malaysia Academy of Sciences (06-2015)
3. DOW Chemicals Sustainability Innovation Student Challenge (DOW SISCA) Award Winner (10-2013)
4. KAUST PhD Fellowship and Provost Awards (09-2011)
WEBSITES:
ResearchGate
https://www.researchgate.net/profile/Aloysius_Wong
Google Scholar
https://scholar.google.com/citations?user=w434nIEAAAAJ&hl=en
Linkedin
https://www.linkedin.com/in/aloysius-wong-67484819
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