Yu Meng Ph.D.

Education

Ph.D. Biochemistry and Molecular Biology, Clemson University, SC, USA

B.S. Biotechnology, Wuhan University, China

Biography

RUTGERS UNIVERSITY – PISCATAWAY, NJ                                             01/2010-2015

Research Associate in Center for Advanced Biotechnology and Medicine Principal Investigator: Peter Lobel

  • Pharmacokinetics and pharmacodynamics study of a novel peptide mediated intravenous delivery system in preclinical mouse model of a neurodegenerative lysosomal storage disease (Late infantile neuronal ceroid lipofuscinosis-LINCL).
  • Investigation of the molecular mechanism of the novel peptide in mediating delivery of large molecule therapeutics across blood brain barrier into the brain.
  • Characterization of intrathecal enzyme replacement therapy for LINCL.  Identification of biomarkers in LINCL mouse model.

CLEMSON UNIVERSITY – CLEMSON, SC                                               08/2005-12/2009

Graduate Research Assistant in Department of Genetics and Biochemistry

  • Expression and purification of an archaeal medium-chain acyl-CoA synthetase (ACS).  Characterization of the enzymatic mechanism of ACS.
  • Construction, production and structure modeling of ACS variants.

CHINESE ACADEMY OF SCIENCE – BEIJING, CHINA                           01/2004-06/2004

Research Assistant in Molecular Microbiology Research Center

  • Molecular cloning of system specific promoter and construct expression vectors for C4 plant

Research interests

  • Drug delivery system; Protein engineering; Neurodegenerative disease
  • Efficacy and mechanism study of the effective drug carrier targeting at the blood-brain barrier for the treatment of a series of neurodegenerative disorders.

Research Project

National Natural Science Foundation of China Program

Mechanism of a novel and efficient in-trans drug carrier K16ApoE across the blood-brain barrier

Zhejiang Provincial Natural Science Foundation of China

Study on the mechanism of new peptide carriers mediating drug crossing the blood-brain barrier

Wenzhou Municipal Science and Technology Bureau

Construction of the Chimera by Polypeptide K16ApoE and Lysosomal Enzyme TPP1 and Its Effect on Conquering Blood Brain Barrier

Awards

Grants as PI:

  • National Natural Science Foundation of China (NSFC), Youth Research Award 01/2018-12/2020
  • Zhe Jiang Province Natural Science Foundation (ZJNSF) Research Award 01/2016-12/2018
  • Wenzhou Science and Technology Bureau Research Award       01/2018-12/2019
  • Wenzhou-Kean University Student Partnering Faculty (SpF) Research Award 11/2015-06/2016

Selected Publication

  • Michelena, X. Tian, X. Zhou, Y. Meng. “The Impact on the Activity of Acetylcholinesterase of a Polylysine-ApoE Peptide Carrier Targeting the Blood Brain Barrier”, Fundam. Toxicol. Sci., 2018, 5(3): 123-126.
  • Meng, J. Wiseman, Y. Nemtsova, D. Moore, J. Guevarra, K. Reuhl, W. Banks, R. Daneman, D. Sleat, P. Lobel. “A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism”, Molecular Therapy, 2017, pii: S1525-0016(17)30158-2.
  • Wiseman, Y. Meng, Y. Nemtsova, P. Matteson, J. Millonig, D. Moore, D. Sleat, P. Lobel. “Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease”, Mol Ther Methods Clin Dev, 2017, 4:204-212.
  • Meng. “The Role of a Conserved Tryptophan Residue in Acetyl-Coenzyme A Synthetase”, Chinese Journal of Biochemistry and Molecular Biology, 2016, 32:1219-1226.
  • Meng, I. Sohar, D. Sleat, R. Jenkins, G. Sarkar, J. Richardson, P. Lobel. “Effective treatment of late-infantile neuronal ceroid lipofuscinosis by peptide-mediated delivery of tripeptidyl peptidase I across the blood-brain barrier in a mouse model”, Molecular Therapy, 2014, 22: 547-53.