温州肯恩大学校长王立教授课题组研究苯硼酸基智能闭环胰岛素控释系统获新进展

糖尿病是血糖调节紊乱引起的一种慢性疾病。据国际糖尿病联合会统计,2017年球糖尿病患者人数已达4.25亿。胰岛素对维持糖尿病患者的正常血糖水平非常重要,注射是目前胰岛素给药的主要方式,但它的不方便及疼痛等一直困扰着患者。因此为患者提供安全、方便、少痛苦的胰岛素输入方式一直是糖尿病治疗追求的目标。

苯硼酸基智能闭环胰岛素控释系统利用苯硼酸基团对葡萄糖的响应性能模拟胰腺的工作模式,实现随着血糖浓度的变化智能调节胰岛素释放的目的。

王立教授和俞豪杰副教授课题组系统地综述了苯硼酸基智能闭环胰岛素控释系统的研究进展,该工作近期发表在Journal of Controlled Release上。

苯硼酸基智能闭环胰岛素控释系统能根据血糖浓度自适应地调节胰岛素的释放量,有效避免低血糖及临床上频繁注射胰岛素给糖尿病患者带来的组织和神经损伤及精神压力,减少给药次数,提高患者的心理依从性。该智能闭环胰岛素控释系统利用苯硼酸及其衍生物能与葡萄糖的二醇结构可逆共价结合的特性,将其作为葡萄糖响应单元,实现葡萄糖响应的胰岛素控制释放,其控释机理主要可分为:溶胀释放、降解释放、竞争取代释放三种。


图为水凝胶、胶束、核-壳-冠结构载体和层层包覆胶囊的葡萄糖响应释药机理示意图。

许多苯硼酸基智能闭环胰岛素控释系统在糖尿病鼠实验中表现出了优良的血糖控制效果,但其和临床应用相关的性能等还有待进一步评估;将苯硼酸基智能闭环胰岛素控释系统与一些更易于大众接受的给药方式(如口服、微针给药等)结合起来,有望开发出更受糖尿病患者欢迎的产品。

团队负责人简介:

王立,现为温州肯恩大学校长、浙江大学求是特聘教授、博士生导师、英国皇家化学会会士,享受政府特殊津贴,先后担任浙江大学国际教育学院院长、浙江大学外事处副处长、美国Yale University访问教授、美国University of Washington访问教授、美国University of California, Irvine访问教授、中国物理学会波谱学专业委员会委员、浙江省化学会常务理事等职。已从事功能高分子、纳米材料、自组装、树枝状分子、配位聚合等方面的研究多年,已在Chemical Reviews、Progress in Polymer Science、Angewandte Chemie-International Edition、Macromolecules、Nanotechnology等学术期刊发表SCI、EI收录论文300余篇

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Social media era
Star gossip
Subversive news
Subway newspaper
The consequences of gossip
theme
topic
travel
Trivial things
TV gossip
Unique dynamics
Who is the rumor girl
Why do women say gossip
Workplace
Workplace conflict
Written communication
Analysis information
Animation
Blog
business
Buzzword
celebrity
Celebrity gossip
Channel
chat
collect information
broadcast
communicate with
Communication channel
Confidential Information
conversation
Danger
data
dialogue
Discrimination
Dissemination of information
Drama
Education career
Educational information
Emotional story
Encyclopedia entry
entertainment
Entertainment industry
Evolutionary psychology
expert
Express ideas
Female blog
Gossip
Gossip 99
Gossip culture
gossip Girl
Gossip influence
Gossip Lanca
Gossip man
Gossip meaning
Gossip meaning in Hindi
Gossip meaning in Urdu
Gossip watch
Gossipstar
Harassment
Hollywood gossip
How to avoid gossip
Human Resources
Information consumption
Information gap
Information Sharing
magazine
management
Man’s gossip
mask
media
Melodrama
Modern fashion
news
News gossip
Newsletter
Office gossip policy
Office teasing
opinion
physical education
play games
political
Productivity decline
profession
professional
Professional trap
Rate gossip
report
reputation
Resource
revolution
Rule of thumb
Rumor
Sensational
Sensitive information
Sharing secrets
Social
Social media era
Star gossip
Subversive news
Subway newspaper

theme
topic
travel
Trivial things
TV gossip
Unique dynamics
Who is the rumor girl
Why do women say gossip
Workplace
Workplace conflict
Written communication
Analysis information
Animation
Blog
broadcast
business
Buzzword
celebrity
Celebrity gossip
Channel
chat
collect information
communicate with
Communication channel
Confidential Information
conversation
Danger
data
dialogue
Discrimination
Dissemination of information
Drama
Education career
Educational information
Emotional story
Encyclopedia entry
entertainment
Entertainment industry
Evolutionary psychology
expert
Express ideas
Female blog
Gossip
Gossip 99
Gossip culture
gossip Girl
Gossip influence
Gossip Lanca
Gossip man
Gossip meaning
Gossip meaning in Hindi
Gossip meaning in Urdu
Gossip watch
Gossipstar
Harassment
Hollywood gossip
How to avoid gossip
Human Resources
Information consumption
Information gap
Information Sharing
magazine
management
Man’s gossip
mask
media
Melodrama
Modern fashion
news
News gossip
Newsletter
Office gossip policy
Office teasing
opinion
physical education
play games
political
Productivity decline
profession
professional
Professional trap
Rate gossip
report
reputation
Resource
revolution
Rule of thumb
Rumor
Sensational
Sensitive information
Sharing secrets
Social
Social media era
Star gossip
Subversive news
Subway newspaper
The consequences of gossip
theme
topic
travel
Trivial things
TV gossip
Unique dynamics
Who is the rumor girl
Why do women say gossip
Workplace
Workplace conflict
Written communication
Analysis information
Animation
Blog
broadcast
business
Buzzword
celebrity
Celebrity gossip
Channel
chat
collect information
communicate with
Communication channel
Confidential Information
conversation
Danger
data
dialogue
Dissemination of information
Drama
Education career
Educational information
Emotional story
Encyclopedia entry
entertainment
Entertainment industry
Evolutionary psychology
expert
Express ideas
Female blog
Gossip
Gossip 99
Gossip culture
gossip Girl
Gossip influence
Gossip Lanca
Gossip man
Gossip meaning
Gossip meaning in Hindi
Gossip meaning in Urdu
Gossip watch
Gossipstar
Harassment
Hollywood gossip
How to avoid gossip
Human Resources
Information consumption
Information gap
Information Sharing
magazine
management
Man’s gossip
mask
media
Melodrama
Modern fashion
news
News gossip
Newsletter
Office gossip policy
Office teasing
opinion
physical education
play games
political
Productivity decline
profession
professional
Professional trap
Rate gossip
report
reputation
Resource
revolution
Rule of thumb
Rumor
Sensational
Sensitive information
Sharing secrets
Social
Social media era
Star gossip
Subversive news
Subway newspaper
The consequences of gossip
theme
topic
travel
Trivial things
TV gossip
Unique dynamics
Who is the rumor girl
Why do women say gossip
Workplace
Workplace conflict
Written communication